Since 1986, H. Adam Steinberg has worked on hundreds of publications, grants, books, pitch decks, and other research proposals. Let me help you get yours published or funded! (List is not inclusive.)

Comparing Galactan Biosynthesis in Mycobacterium tuberculosis and Corynebacterium diphtheriae
Darryl A. Wesener, Matthew R. Levengood, and Laura L. Kiessling
J. Biol. Chem., Feb 2017; 292: 2944 - 2955.

 

Molecular basis for the autonomous promotion of cell proliferation by angiogenin
Trish T. Hoang and Ronald T. Raines
Nucleic Acids Res., Jan 2017; 45: 818 - 831.

Peptide tessellation yields micrometre-scale collagen triple helices.

I. Caglar Tanrikulu, Audrey Forticaux, Song Jin, and Ronald T. Raines (2016).

Nature Chemistry 8, 1008–1014.

 

High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells.

Steyer B, Carlson-Stevermer J, Angenent-Mari N, Khalil A, Harkness T, Saha K.

Acta Biomater. 2016 Apr 1;34:143-58. doi: 10.1016/j.actbio.2015.12.036.

 

Classification and evolution of human rhinoviruses.

Palmenberg AC, Gern JE.

Methods Mol Biol. 2015;1221:1-10. doi: 10.1007/978-1-4939-1571-2_1.

Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm.

Lippmann ES, Williams CE, Ruhl DA, Estevez-Silva MC, Chapman ER, Coon JJ, Ashton RS.

Stem Cell Reports. 2015 Apr 14;4(4):632-44. doi: 10.1016/j.stemcr.2015.02.018.

 

Host ESCRT proteins are required for bromovirus RNA replication compartment assembly and function.

Diaz A, Zhang J, Ollwerther A, Wang X, Ahlquist P.

PLoS Pathog. 2015 Mar 6;11(3):e1004742. doi: 10.1371/journal.ppat.1004742. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004845.

Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins
Paul J. Wrighton, Joseph R. Klim, Brandon A. Hernandez, Chad H. Koonce, Timothy J. Kamp, and Laura L. Kiessling
PNAS, Dec 2014; 111: 18126 - 18131

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification
Samira Musah, Paul J. Wrighton, Yefim Zaltsman, Xiaofen Zhong, Stefan Zorn, Matthew B. Parlato, Cheston Hsiao, Sean P. Palecek, Qiang Chang, William L. Murphy, and Laura L. Kiessling
PNAS, Sep 2014; 111: 13805 - 13810.

 

Spindlegate: the biological consequences of disrupting traffic.

Gnazzo MM, Skop AR.

Dev Cell. 2014 Mar 10;28(5):480-2. doi: 10.1016/j.devcel.2014.02.014.

Flagellum Density Regulates Proteus mirabilis Swarmer Cell Motility in Viscous Environments
Hannah H. Tuson, Matthew F. Copeland, Sonia Carey, Ryan Sacotte, and Douglas B. Weibel
J. Bacteriol., Jan 2013; 195: 368 - 377.

 

Isotope-coded affinity tags with tunable reactivities for protein footprinting

Underbakke ES, Zhu Y, Kiessling LL
Angew Chem Int Ed Engl : 47 : 9677-80 : Pending Publication Date

 

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Douglas R. Davies, Amy D. Gelinas, Chi Zhang, John C. Rohloff, Jeffrey D. Carter, Daniel O’Connell, Sheela M. Waugh, Steven K. Wolk, Wesley S. Mayfield, Alex B. Burgin, Thomas E. Edwards, Lance J. Stewart, Larry Gold, Nebojsa Janjic, and Thale C. Jarvis
PNAS, Dec 2012; 109: 19971 - 19976

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Davies DR, Gelinas AD, Zhang C, Rohloff JC, Carter JD, O'Connell D, Waugh SM and 8 others
Proc Natl Acad Sci U S A : November 8, 2012

 

Ditching Invading DNA

Jinek et al.
Science, Aug 2012; 337: 775.

DOI: 10.1126/science.337.6096.775-f

 

Role of host reticulon proteins in rearranging membranes for positive-strand RNA virus replication.

Diaz A, Ahlquist P.

Curr Opin Microbiol. 2012 Aug;15(4):519-24. doi: 10.1016/j.mib.2012.04.007. Review.

 

Measuring the stiffness of bacterial cells from growth rates in hydrogels of tunable elasticity
Tuson HH, Auer GK, Renner LD, Hasebe M, Tropini C, Salick M, Crone WC, Gopinathan A, Huang KC, Weibel DB
Mol Microbiol : 84 : 874-91 : June 1, 2012

Polyacrylamide hydrogels as substrates for studying bacteria
Tuson HH, Renner LD, Weibel DB
Chem Commun (Camb) : 48 : 1595-7 : February 1, 2012

 

Rational design and evaluation of mammalian ribonuclease cytotoxins.

Jo E. Lomax, Chelcie H. Eller, and Ronald T. Raines

(2012). Methods in Enzymology 502, 273–290.

Structural Role of the Terminal Disulfide Bond in the Sweetness of Brazzein
Sannali M. Dittli, Hongyu Rao, Marco Tonelli, Jeniffer Quijada, John L. Markley, Marianna Max, and Fariba Assadi-Porter
Chem Senses, Nov 2011; 36: 821 - 830.

Spatial control of cell fate using synthetic surfaces to potentiate TGF-β signaling
Lingyin Li, Joseph R. Klim, Ratmir Derda, Adam H. Courtney, and Laura L. Kiessling
PNAS, Jul 2011; 108: 11745 - 11750.


Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
Zachar Z, Marecek J, Maturo C, Gupta S, Stuart SD, Howell K, Schauble A and 7 others
J Mol Med (Berl) : July 19, 2011

Physicochemical regulation of biofilm formation
Renner LD, Weibel DB
MRS Bull : 36 : 347-355 : May 1, 2011

 

Stacking interactions in PUF–RNA complexes
Yvonne Yiling Koh, Yeming Wang, Chen Qiu, Laura Opperman, Leah Gross, Traci M. Tanaka Hall, and Marvin Wickens
RNA, Apr 2011; 17: 718 - 727

Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes
Lars D. Renner and Douglas B. Weibel
PNAS, Apr 2011; 108: 6264 - 6269.

 

Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function.

Diaz A, Wang X, Ahlquist P.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16291-6. doi: 10.1073/pnas.1011105107.

 

Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories.

den Boon JA, Ahlquist P.

Annu Rev Microbiol. 2010;64:241-56. doi: 10.1146/annurev.micro.112408.134012. Review.

 

P. aeruginosa PilT structures with and without nucleotide reveal a dynamic type IV pilus retraction motor.
Misic AM, Satyshur KA, Forest KT
J Mol Biol. 2010 Jul 30;400(5):1011-21.

 

Cytoplasmic viral replication complexes.

den Boon JA, Diaz A, Ahlquist P.

Cell Host Microbe. 2010 Jul 22;8(1):77-85. doi: 10.1016/j.chom.2010.06.010. Review.


Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor
Assadi-Porter FM, Maillet EL, Radek JT, Quijada J, Markley JL, Max M
J Mol Biol : 398 : 584-99 : May 14, 2010

Specificity landscapes of DNA binding molecules elucidate biological function
Carlson CD, Warren CL, Hauschild KE, Ozers MS, Qadir N, Bhimsaria D, Lee Y, Cerrina F, Ansari AZ
Proc Natl Acad Sci U S A : 107 : 4544-9 : March 9, 2010

 

Studying the Dynamics of Flagella in Multicellular Communities of Escherichia coli by Using Biarsenical Dyes
Matthew F. Copeland, Shane T. Flickinger, Hannah H. Tuson, and Douglas B. Weibel
Appl. Envir. Microbiol., Feb 2010; 76: 1241 - 1250.


Disassembly of Escherichia coli RecA E38K/DeltaC17 nucleoprotein filaments is required to complete DNA strand exchange
Britt RL, Haruta N, Lusetti SL, Chitteni-Pattu S, Inman RB, Cox MM
J Biol Chem : 285 : 3211-26 : January 29, 2010

A tethering mechanism for length control in a processive carbohydrate polymerization
John F. May, Rebecca A. Splain, Christine Brotschi, and Laura L. Kiessling
PNAS, Jul 2009; 106: 11851 - 11856.


Role of band 3 in regulating metabolic flux of red blood cells
Lewis IA, Campanella ME, Markley JL, Low PS
Proc Natl Acad Sci U S A : 106 : 18515-20 : November 3, 2009

 

Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution
Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, Rathe JA, Fraser-Liggett CM, Liggett SB
Science : 324 : 55-9 : April 3, 2009

An amphipathic alpha-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function
Liu L, Westler WM, den Boon JA, Wang X, Diaz A, Steinberg HA, Ahlquist P
PLoS Pathog. 2009 Mar;5(3):e1000351. Epub 2009 Mar 27.

Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution.
Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, Rathe JA, Fraser-Liggett CM, Liggett SB.
Science. 2009 Apr 3;324(5923):55-9. Epub 2009 Feb 12.

Fabrication of Microbial Biofilm Arrays by Geometric Control of Cell Adhesion.
Eun YJ, Weibel DB.
Langmuir. 2009 Feb 12.

The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis
Patel FB, Bernadskaya YY, Chen E, Jobanputra A, Pooladi Z, Freeman KL, Gally C, Mohler WA, Soto MC
Dev Biol : 324 : 297-309 : December 15, 2008

The pipeline. Scientific teaching in practice
Miller S, Pfund C, Pribbenow CM, Handelsman J
Science. 2008 Nov 28;322(5906):1329-30

Adipocyte metabolism and obesity
Attie AD, Scherer PE
J Lipid Res. 2008 Nov 17.

The interaction between an acidic transcriptional activator and its inhibitor. The molecular basis of Gal4p recognition by Gal80p
Thoden JB, Ryan LA, Reece RJ, Holden HM
J Biol Chem. 2008 Oct 31;283(44):30266-72. Epub 2008 Aug 13

Evolution of our understanding of vitamin D
DeLuca HF
Nutr Rev. 2008 Oct;66(10 Suppl 2):S73-87.

How to get a cow pregnant
Grow  Magazine, Fall 2008, Wisconsin's Magazine for the Life Sciences

In Planta Analysis of the Cell Cycle-Dependent Localization of AtCDC48A and Its Critical Roles in Cell Division, Expansion, and Differentiation
Sookhee Park, David Michael Rancour, and Sebastian York Bednarek
Plant Physiology, Sep 2008; 148: 246 - 258.

 

A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity
Craig R. Stumpf, Judith Kimble, and Marvin Wickens
RNA, Aug 2008; 14: 1550 - 1557.

 

Structure, mechanism and regulation of pyruvate carboxylase
Jitrapakdee S, St Maurice M, Rayment I, Cleland WW, Wallace JC, Attwood PV
Biochem J. 2008 Aug 1;413(3):369-87

 

How to make DNA
Grow  Summer 2008, Wisconsin's Magazine for the Life Sciences

 

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
Keller MP, Choi Y, Wang P, Belt Davis D, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD
Genome Res. 2008 May;18(5):706-16.

 

Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR
Fariba M. Assadi-Porter, Marco Tonelli, Emeline Maillet, Klaas Hallenga, Outhiriaradjou Benard, Marianna Max,‡ and John L. Markley
J. Am. Chem. Soc., 130 (23), 7212–7213, 2008

 

The C. elegans SYS-1 protein is a bona fide beta-catenin
Liu J, Phillips BT, Amaya MF, Kimble J, Xu W
Dev Cell. 2008 May;14(5):751-61.

 

Isotope-coded affinity tags with tunable reactivities for protein footprinting
Underbakke ES, Zhu Y, Kiessling LL
Angew Chem Int Ed Engl. 2008;47(50):9677-80.

 

Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly
Moretti R, Donato LJ, Brezinski ML, Stafford RL, Hoff H, Thorson JS, Dervan PB, Ansari AZ
ACS Chem Biol. 2008 Apr 18;3(4):220-9.

 

Structural dependencies of protein backbone 2JNC couplings
Nenad Jurani, J.J. Dannenberg, Gabriel Cornilescu, Pedro Salvador, Elena Atanasova, Hee-Chul Ahn, Slobodan Macura, John L. Markley, Franklyn G. Prendergast
Protein Sci. 2008 Apr;17(4):768-76. Epub 2008 Feb 27.[Link to article]

 

Bright ideas for chemical biology
Lavis LD, Raines RT
ACS Chem Biol. 2008 Mar 20;3(3):142-55. Review.

 

A rapid, microplate SNP genotype assay for the leptinob allele.
Oler AT, Attie AD.J
Lipid Res. 2008 May;49(5):1126-9. Epub 2008 Feb 13.

 

How to study the smell of cheese
Grow    Winter 2008, Wisconsin's Magazine for the Life Sciences

 

Synaptotagmin C2A Loop 2 Mediates Ca2+-dependent SNARE Interactions Essential for Ca2+-triggered Vesicle Exocytosis
K. L. Lynch, R.R.L. Gerona, E. C. Larsen, R. F. Marcia, J. C. Mitchell, and T.F.J. Martin
Mol Biol Cell. 2007 Dec;18(12):4957-68.

 

How to see a protein
Grow    Fall 2007, Wisconsin's Magazine for the Life Sciences

Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers
Derda R, Wherritt DJ, Kiessling LL
Langmuir. 2007 Oct 23;23(22):11164-7. Epub 2007 Sep 20.[Link to article]

Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme
St Maurice M, Reinhardt L, Surinya KH, Attwood PV, Wallace JC, Cleland WW, Rayment I
Science. 2007 Aug 24;317(5841):1076-9

 

SORCS1: A Novel Human Type 2 Diabetes Susceptibility Gene Suggested by the Mouse
Mark O. Goodarzi, Donna M. Lehman, Kent D. Taylor, Xiuqing Guo, Jinrui Cui, Manuel J. Quiñones, Susanne M. Clee, Brian S. Yandell, John Blangero, Willa A. Hsueh, Alan D. Attie, Michael P. Stern, and Jerome I. Rotter
Diabetes, Jul 2007; 56: 1922 - 1929

Defined substrates for human embryonic stem cell growth identified from surface arrays
Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL
ACS Chem Biol. 2007 May 22;2(5):347-55.

 

Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
Dohun Pyeon, Michael A. Newton, Paul F. Lambert, Johan A. den Boon, Srikumar Sengupta, Carmen J. Marsit, Craig D. Woodworth, Joseph P. Connor, Thomas H. Haugen, Elaine M. Smith, Karl T. Kelsey, Lubomir P. Turek, and Paul Ahlquist
Cancer Res., May 2007; 67: 4605 - 461


Activating B cell signaling with defined multivalent ligands
Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL
ACS Chem Biol. 2007 Apr 24;2(4):252-62.

1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site
Fretz JA, Zella LA, Kim S, Shevde NK, Pike JW
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):440-5.

ABCA1: at the nexus of cholesterol, HDL and atherosclerosis
Attie AD
Trends Biochem Sci. 2007 Apr;32(4):172-9. Epub 2007 Feb 26. Review.

Selective tumor cell targeting using low-affinity, multivalent interactions
Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL
ACS Chem Biol. 2007 Feb 20;2(2):119-27.

Regulation of bacterial RecA protein function
Cox MM
Crit Rev Biochem Mol Biol. 2007 Jan-Feb;42(1):41-63. Review.

Understanding a transcriptional paradigm at the molecular level. The structure of yeast Gal80p
Thoden JB, Sellick CA, Reece RJ, Holden HM
J Biol Chem. 2007 Jan 19;282(3):1534-8. Epub 2006 Nov 22

Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3
Zella LA, Kim S, Shevde NK, Pike JW

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):435-9. Epub 2007 Jan 10.
 

Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3
Kim S, Yamazaki M, Zella LA, Meyer MB, Fretz JA, Shevde NK, Pike JW
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):430-4. Epub 2007 Jan 2.

 

Positional cloning of a type 2 diabetes quanitative trait locus
Clee, S.M., Yandell, B.S., Schueler, K.M., Rabaglia, M.E., Richards, O.C., Raines, S.M., Kabara, E.A., Klass, D.M., Stapleton, D.S., Gray-Keller, M.P., Boronenkov, I., Raess, P.W., Flowers, M.T., and Attie, A.D
Nature Genetics 38,688-693 2006

 

Activation of Receptor Activator of NF-B Ligand Gene Expression by 1,25-Dihydroxyvitamin D3 Is Mediated through Multiple Long-Range Enhancers
Sungtae Kim, Miwa Yamazaki, Lee A. Zella, Nirupama K. Shevde, and J. Wesley Pike
Mol. Cell. Biol., Sep 2006; 26: 6469 - 6486

Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3
Zella LA, Kim S, Shevde NK, Pike JW
Mol Endocrinol. 2006 Jun; 20(6):1231-47

 

Membrane Association, Mechanism of Action, and Structure of Arabidopsis Embryonic Factor 1 (FAC1)
Byung Woo Han, Craig A. Bingman, Donna K. Mahnke, Ryan M. Bannen, Sebastian Y. Bednarek, Richard L. Sabina, and George N. Phillips, Jr
J. Biol. Chem., May 2006; 281: 14939 - 14947.

Membrane Topology of Mouse Stearoyl-CoA Desaturase 1
Weng Chi Man, Makoto Miyazaki, Kiki Chu, and James M. Ntambi
J. Biol. Chem., Jan 2006; 281: 1251 - 1260

Correlation of the Sweetness of Variants of the Protein Brazzein with Patterns of Hydrogen Bonds Detected by NMR Spectroscopy
Fariba M. Assadi-Porter, Frits Abildgaard, Heike Blad, and John L. Markley
J. Biol. Chem., Aug 2003; 278: 31331 - 31339.

Cytoplasmic and Nuclear Delivery of a TAT-derived Peptide and a β-Peptide after Endocytic Uptake into HeLa Cells
Terra B. Potocky, Anant K. Menon, and Samuel H. Gellman
J. Biol. Chem., Dec 2003; 278: 50188 - 50194

Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B
Donald L. Gillian-Daniel, Paul W. Bates, Angie Tebon, and Alan D. Attie
PNAS, Apr 2002; 99: 4337 - 4342

Structural Studies of lacUV5-RNA Polymerase Interactions in Vitro. ETHYLATION INTERFERENCE AND MISSING NUCLEOSIDE ANALYSIS
Richard J. Noel, Jr. and William S. Reznikoff
J. Biol. Chem., Mar 2000; 275: 7708 - 7712

Hairpin Formation in Tn5 Transposition
Archna Bhasin, Igor Y. Goryshin, and William S. Reznikoff
J. Biol. Chem., Dec 1999; 274: 37021 - 37029

The Cleavage and Polyadenylation Specificity Factor in Xenopus laevisOocytes Is a Cytoplasmic Factor Involved in Regulated Polyadenylation
Kirsten S. Dickson, Andrea Bilger, Scott Ballantyne, and Marvin P. Wickens
Mol. Cell. Biol., Aug 1999; 19: 5707 - 5717

Modiifcations of the 5' Cap of mRNAs during Xenopus Oocyte Maturation: Independence from Changes in Poly(A) Length and Impact on Translation
Donald L. Gillian-Daniel, Nicola K. Gray, Jonas Åström, Aaron Barkoff, and Marvin Wickens
Mol. Cell. Biol., Oct 1998; 18: 6152 - 616

A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation.
S Ballantyne, D L Daniel, Jr, and M Wickens
Mol. Biol. Cell, Aug 1997; 8: 1633 - 1648

A three-hybrid system to detect RNA-protein interactions in vivo.
D J SenGupta, B Zhang, B Kraemer, P Pochart, S Fields, and M Wickens
PNAS, Aug 1996; 93: 8496 - 8501

Role of the Chlamydomonas reinhardtii Coupling Factor 1 -Subunit Cysteine Bridge in the Regulation of ATP Synthase
Stuart A. Ross, Michael X. Zhang, and Bruce R. Selman
J. Biol. Chem., Apr 1995; 270: 9813 - 9818

The GPI anchor of cell-surface proteins is synthesized on the cytoplasmic face of the endoplasmic reticulum
J Vidugiriene and AK Menon
J. Cell Biol., Oct 1994; 127: 333

Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements.
A Bilger, C A Fox, E Wahle, and M Wickens
Genes & Dev., May 1994; 8: 1106 - 1116

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.
M D Sheets, C A Fox, T Hunt, G Vande Woude, and M Wickens
Genes & Dev., Apr 1994; 8: 926 - 938

Adverse conditions which cause lack of flagella in Escherichia coli.
C Li, C J Louise, W Shi, and J Adler
J. Bacteriol., Apr 1993; 175: 2229 - 2235

Role of maturation cleavage in infectivity of picornaviruses: activation of an infectosome.
W M Lee, S S Monroe, and R R Rueckert
J. Virol., Apr 1993; 67: 2110 - 2122.

Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.
W Forrester, F Stutz, M Rosbash, and M Wickens
Genes & Dev., Oct 1992; 6: 1914 - 1926.